Key References

KEY REFERENCES FOR DOSE-EFFECT ANALYSIS FROM CHOU ET AL
(* Primary References)

I. For Single Drugs

  • Chou, T.-C. Relationships between inhibition constants and fractional inhibitions in enzyme-catalyzed reactions with different numbers of reactants, different reaction mechanisms, and different types of mechanisms of inhibition. Mol. Pharmacol. 10: 235-247, 1974. For statistics of citation, click here to download the Citation Map.
  • * Chou, T.-C. Derivation and properties of Michaelis-Menten type and Hill type equations for reference ligands. J. Theoret. Biol. 39: 253-276, 1976. For statistics of citation, click here to download the Citation Map.
  • Chou, T.-C. On the determination of availability of ligand binding sites in steady-state systems. J. Theoret. Biol. 65: 345-356, 1977.
  • Chou, T.-C. Comparison of dose-effect relationships of carcinogens following low-dose chronic exposure and high- dose single injection; An analysis by the median-effect principle. Carcinogenesis 1: 203-213, 1980.

II. For Drug Combinations

  • Chou, T.-C. and Talalay, P. A simple generalized equation for the analysis of multiple inhibtions of Michaelis-Menten kinetic systems. J. Biol. Chem. 252: 6438-6442, 1977. For statistics of citation, click here to download the Citation Map.
  • * Chou, T.-C. and Talalay, P. Generalized equations for the analysis of inhibitors of Michaelis-Menten and higher order kinetic systems with two or more mutally exclusive and nonexclusive inhibitors. Europ. J. Biochem. 115: 207-216, 1981. For statistics of citation, click here to download the Citation Map.
  • * Chou, T.-C. and Talalay, P. Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors. Adv. Enz. Regul. 22: 27-55, 1984. (Cited in 1,915 scientific articles in over 381 biomedical journals). For statistics of citation, click here to download the Citation Map.
  • Chou, T.-C. and Talalay, P. Applications of the median-effect principle for the assessment of low-dose risk of carcinogens and for the quantitation of synergism and antagonism of chemotherapeutic agents. In New Avenues in Developmental Cancer Chemotherapy, Bristol-Myers Symposium series, K.R. Harrap, and T.A. Connors Eds., pp. 37-64, New York, Academic Press, 1987.
  • Chou, T.-C. Quantitative dose-effect analysis and algorithms: A theoretical study. Asia Pacific J. Pharmacol. 2: 93-99, 1987.
  • Chou, T.-C., Rideout, D., Chou, J. and Bertino, J.R. Chemotherapeutic synergism, potentiation and antagonism. In Encyclopedia of Human Biology, Dulbecco, R. (Ed), Academic Press, vol. 2, pp. 371-379, 1991.
  • Chou, T.-C. The median-effect principle and the combination index for quantiation of synergism and antagonism. In Synergism and antagonism in chemotherapy (Chou, T.-C. and Rideout, D.C., eds.) pp. 61-102, Academic Press, San Diego, 1991.
  • * Chou, T.-C., Motzer, R.J., Tong, Y. and Bosi, G.J. Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against teratocarcinoma cell growth: A rational approach to clinical protocol design. J. Nat’l Cancer Inst. 86: 1517-1524, 1994. (Highlighted paper with an editorial) (Sample data analysis available) . For statistics of citation, click here to download the Citation Map.
  • Bertino, J.R. and Chou, T.-C. Chemotherapy: Synergism and Antagonism. In Encyclopedia of Cancer, Bertino, J.R. Vol.1. pp. 368-79. Academic Press, San Diego, 1997.
  • * Chou, T.-C. Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies. Pharmacological Reviews 58:621-681, 2006 and 128 pages of Appendix for Examples of Computer Printouts.
    Free Web Link:     http://pharmrev.aspetjournals.org/cgi/reprint/58/3/621
    For statistics of citation, click here to download the Citation Map.
  • Chou, T.-C. What is synergy? The Scientist 21: No. 8, p. 15, 2007. (An Open Forum)
  • * Chou, T.-C. Preclinical versus clinical drug combination studies. Leukemia & Lymphoma 49: 2059-2080, 2008. (Clinical Discussions)(Sample Computer Printouts for Drug Combinations for 2 and 3 Drugs in vitro)
  • Chou, T.-C. The mass-action law based GPS concept for bio-informatics. Nature Precedings (npre.2008.2064-2); July 22, 2008. Available free at http://precedings.nature.com/documents/2064/version/2.

III. Computer Software

  • Chou, J and Chou, T.-C. Dose-effect analysis with microcomputers: Quantitation of ED50, LD50, synergism, antagonism, low-dose risk, receptor-ligand binding and enzyme kinetics. Manual and Software, Biosoft, Cambridge, U.K., 1987.
  • Chou, T.-C. and Hayball, M. CalcuSyn for Windows, Multiple-drug dose-effect analyzer and manual. Biosoft, Cambridge Place, Cambrige, UK. 1996.
  • * Chou, T.-C. and Martin, N. CompuSyn for Drug Combinations and for General Dose-Effect Analysis. Software for quantitation of synergism and antagonism and determination of IC50, ED50 and LD50. ComboSyn, Inc. Paramus, NJ, 2006.
Info: WWW.ComboSyn.Com, e-mail: ComboSyn@gmail.com


Total Citations for Chou’s theoretical work: 3,970 (as of 07/31/2009)

^ TOP

Copyright © 2006-2009 ComboSyn Incorporated, All Rights Reserved.
P.O. Box 1277 Paramus, NJ 07653-1277 | Tel: 201-251-8812
Web: www.ComboSyn.com | E-mail: ComboSyn@gmail.com
Web Site Developed & Hosted by MIG, Inc.