Key References
KEY REFERENCES FOR DOSE-EFFECT ANALYSIS FROM CHOU ET AL
(
* Primary References)
I. For Single Drugs
- Chou, T.-C. Relationships between inhibition constants and fractional
inhibitions in enzyme-catalyzed reactions with different numbers of reactants,
different reaction mechanisms, and different types of mechanisms of inhibition.
Mol. Pharmacol. 10: 235-247, 1974.
- * Chou, T.-C. Derivation and properties
of Michaelis-Menten type and Hill type equations for reference ligands.
J. Theoret. Biol. 39: 253-276, 1976.
- Chou, T.-C. On the determination of availability of ligand binding sites
in steady-state systems. J. Theoret. Biol. 65: 345-356, 1977.
- Chou, T.-C. Comparison of dose-effect relationships of carcinogens following
low-dose chronic exposure and high- dose single injection; An analysis
by the median-effect principle. Carcinogenesis 1: 203-213, 1980.
II. For Drug Combinations
- Chou, T.-C. and Talalay, P. A simple generalized equation for the analysis
of multiple inhibtions of Michaelis-Menten kinetic systems. J. Biol. Chem.
252: 6438-6442, 1977.
- * Chou, T.-C. and Talalay, P. Generalized
equations for the analysis of inhibitors of Michaelis-Menten and higher
order kinetic systems with two or more mutally exclusive and nonexclusive
inhibitors. Europ. J. Biochem. 115: 207-216, 1981.
- * Chou, T.-C. and Talalay, P. Quantitative
analysis of dose-effect relationships:
The combined effects of multiple drugs or enzyme inhibitors. Adv. Enz.
Regul. 22: 27-55, 1984. (Cited in 1,286 scientific articles in biomedical journals)
- Chou, T.-C. and Talalay, P. Applications of the median-effect principle
for the assessment of low-dose risk of carcinogens and for the quantitation
of synergism and antagonism of chemotherapeutic agents. In New Avenues
in Developmental Cancer Chemotherapy, Bristol-Myers Symposium series,
K.R. Harrap, and T.A. Connors Eds., pp. 37-64, New York, Academic
Press, 1987.
- Chou, T.-C. Quantitative dose-effect analysis and algorithms: A theoretical
study. Asia Pacific J. Pharmacol. 2: 93-99, 1987.
- Chou, T.-C., Rideout, D., Chou, J. and Bertino, J.R. Chemotherapeutic
synergism, potentiation and antagonism. In Encyclopedia of Human Biology,
Dulbecco, R. (Ed), Academic Press, vol. 2, pp. 371-379, 1991.
- * Chou, T.-C. The median-effect principle
and the combination index for quantiation of synergism and antagonism.
In Synergism and antagonism in chemotherapy (Chou, T.-C. and Rideout,
D.C., eds.) pp. 61-102, Academic Press, San Diego, 1991.
- * Chou, T.-C., Motzer, R.J., Tong, Y.
and Bosi, G.J. Computerized quantitation of synergism and antagonism
of taxol, topotecan, and cisplatin against teratocarcinoma cell growth:
A rational approach to clinical protocol design. J. Nat’l Cancer
Inst. 86: 1517-1524, 1994. (Highlighted
paper with an editorial)
Bertino, J.R. and Chou, T.-C. Chemotherapy: Synergism and Antagonism.
In Encyclopedia of Cancer, Bertino, J.R. Vol.1.
pp. 368-79. Academic Press, San Diego, 1997.
- * Chou, T.-C. Theoretical Basis, Experimental
Design, and Computerized Simulation of Synergism and Antagonism in Drug
Combination Studies. Pharmacological Reviews
58:621-681, 2006 [For Web & Supplementary Information, Link:
http://pharmrev.aspetjournals.org/cgi/content/abstract/58/3/621
or library]. (The journal
impact factor is 30.387 which ranks No. 7 among >3,000 science journals)
III. Computer Software
- Chou, J and Chou, T.-C. Dose-effect analysis with microcomputers:
Quantitation of ED50, LD50,
synergism, antagonism, low-dose risk, receptor-ligand binding and enzyme
kinetics. Manual and Software, Biosoft, Cambridge, U.K., 1987.
- Chou, T.-C. and Hayball, M. CalcuSyn for Windows, Multiple-drug dose-effect
analyzer and manual. Biosoft, Cambridge Place, Cambrige, UK. 1996.
- * Chou, T.-C. and Martin, N. CompuSyn
for Drug Combinations. Software for quantitation
of synergism and antagonism and determination of IC50, ED50
and LD50. ComboSyn, Inc. Paramus,
NJ, 2005. (New Release July, 2005).
Total Citations for Chou’s theoretical work: 2,669 (as of 12/2004)
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