Key References

KEY REFERENCES FOR DOSE-EFFECT ANALYSIS FROM CHOU ET AL
(* Primary References)

I. For Single Drugs

  • Chou, T.-C. Relationships between inhibition constants and fractional inhibitions in enzyme-catalyzed reactions with different numbers of reactants, different reaction mechanisms, and different types of mechanisms of inhibition. Mol. Pharmacol. 10: 235-247, 1974.
  • * Chou, T.-C. Derivation and properties of Michaelis-Menten type and Hill type equations for reference ligands. J. Theoret. Biol. 39: 253-276, 1976.
  • Chou, T.-C. On the determination of availability of ligand binding sites in steady-state systems. J. Theoret. Biol. 65: 345-356, 1977.
  • Chou, T.-C. Comparison of dose-effect relationships of carcinogens following low-dose chronic exposure and high- dose single injection; An analysis by the median-effect principle. Carcinogenesis 1: 203-213, 1980.

II. For Drug Combinations

  • Chou, T.-C. and Talalay, P. A simple generalized equation for the analysis of multiple inhibtions of Michaelis-Menten kinetic systems. J. Biol. Chem. 252: 6438-6442, 1977.
  • * Chou, T.-C. and Talalay, P. Generalized equations for the analysis of inhibitors of Michaelis-Menten and higher order kinetic systems with two or more mutally exclusive and nonexclusive inhibitors. Europ. J. Biochem. 115: 207-216, 1981.
  • * Chou, T.-C. and Talalay, P. Quantitative analysis of dose-effect relationships:
    The combined effects of multiple drugs or enzyme inhibitors. Adv. Enz. Regul. 22: 27-55, 1984. (Cited in 1,286 scientific articles in biomedical journals)
  • Chou, T.-C. and Talalay, P. Applications of the median-effect principle for the assessment of low-dose risk of carcinogens and for the quantitation of synergism and antagonism of chemotherapeutic agents. In New Avenues in Developmental Cancer Chemotherapy, Bristol-Myers Symposium series, K.R. Harrap, and T.A. Connors Eds., pp. 37-64, New York, Academic Press, 1987.
  • Chou, T.-C. Quantitative dose-effect analysis and algorithms: A theoretical study. Asia Pacific J. Pharmacol. 2: 93-99, 1987.
  • Chou, T.-C., Rideout, D., Chou, J. and Bertino, J.R. Chemotherapeutic synergism, potentiation and antagonism. In Encyclopedia of Human Biology, Dulbecco, R. (Ed), Academic Press, vol. 2, pp. 371-379, 1991.
  • * Chou, T.-C. The median-effect principle and the combination index for quantiation of synergism and antagonism. In Synergism and antagonism in chemotherapy (Chou, T.-C. and Rideout, D.C., eds.) pp. 61-102, Academic Press, San Diego, 1991.
  • * Chou, T.-C., Motzer, R.J., Tong, Y. and Bosi, G.J. Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against teratocarcinoma cell growth: A rational approach to clinical protocol design. J. Nat’l Cancer Inst. 86: 1517-1524, 1994. (Highlighted paper with an editorial)

    Bertino, J.R. and Chou, T.-C. Chemotherapy: Synergism and Antagonism. In Encyclopedia of Cancer, Bertino, J.R. Vol.1. pp. 368-79. Academic Press, San Diego, 1997.
  • * Chou, T.-C. Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies. Pharmacological Reviews 58:621-681, 2006 [For Web & Supplementary Information, Link: http://pharmrev.aspetjournals.org/cgi/content/abstract/58/3/621 or library]. (The journal impact factor is 30.387 which ranks No. 7 among >3,000 science journals)

III. Computer Software

  • Chou, J and Chou, T.-C. Dose-effect analysis with microcomputers: Quantitation of ED50, LD50, synergism, antagonism, low-dose risk, receptor-ligand binding and enzyme kinetics. Manual and Software, Biosoft, Cambridge, U.K., 1987.
  • Chou, T.-C. and Hayball, M. CalcuSyn for Windows, Multiple-drug dose-effect analyzer and manual. Biosoft, Cambridge Place, Cambrige, UK. 1996.
  • * Chou, T.-C. and Martin, N. CompuSyn for Drug Combinations. Software for quantitation of synergism and antagonism and determination of IC50, ED50 and LD50. ComboSyn, Inc. Paramus, NJ, 2005. (New Release July, 2005).
Info: WWW.ComboSyn.Com, e-mail: ComboSyn@gmail.com


Total Citations for Chou’s theoretical work: 2,669 (as of 12/2004)

^ TOP

Copyright © 2006 ComboSyn Incorporated, All Rights Reserved.
P.O. Box 1277 Paramus, NJ 07653-1277 | Tel: 201-251-8812
Web: www.ComboSyn.com | E-mail: ComboSyn@gmail.com
Web Site Developed & Hosted by Sun Tendy USA, Inc.